Bda Library Medline Search Recent Reviews Related to Dental Caries

OBJECTIVES: To answer the following PICO question (participant, intervention, comparator and outcome): Does flowable resin composite restorations compared with regular resin composites improve the marginal adaptation, marginal discoloration and retention rates of restorations placed in non-carious cervical lesions [NCCLs] of adults?, through a systematic review and metaanalysis. SOURCE: MEDLINE, Scopus, Web of Science, LILACS, BBO, Cochrane Library and SIGLE were searched without restrictions, as well as the abstracts of the IADR, clinical trials registries, dissertations and theses in May 2016 (updated in April 2017). STUDY SELECTION: We included randomized clinical trials (RCTs) that answered the PICO question. RCTs were excluded if cavities other than NCCLs were treated; indirect restorations; polyacid-based resins instead of composite resins were employed, restorations in primary teeth and restorations were placed in carious cervical lesions. The risk of bias tool of the Cochrane Collaboration was applied in the eligible studies and the GRADE tool was used to assess the quality of the evidence. DATA: After duplicates removal, 5137 articles were identified. After abstract and title screening, 8 studies remained. Six were at "unclear" risk of bias. The study follow-ups ranged from 1 to 3 years. No significant difference was observed between groups for loss of retention and marginal discoloration in all follow-ups. Better marginal adaptation was observed for restorations performed with flowable composites. At 1-year (risk ratio=0.27 [0.10 to 0.70]) and 3-year (risk ratio=0.34 [0.17 to 0.71]) follow-ups, flowable composites showed a risk 73% and 66% lower than regular composites for lack of adaptation, respectively. The evidence was graded as moderate quality for loss or retention at 3 years due to risk of bias and low and very low for all other outcomes due to risk of bias, imprecision and inconsistency. CONCLUSIONS: We have moderate confidence that the resin composite viscosity does not influence the retention rates at 3 years. Similar marginal discoloration and better marginal adaptation was observed for flowable composites but the quality of evidence is doubtful. (PROSPERO CRD42015019560). Copyright © 2017. Published by Elsevier Ltd. Publication Type Journal Article. Review. Date Created 20170721 Year of Publication 2017 BDA LIBRARY MEDLINE SEARCH RECENT REVIEWS RELATED TO DENTAL CARIES <2> Unique Identifier 28682498 VI 1 Status Publisher Authors Schwendicke F; Splieth CH; Thomson WM; Reda S; Stolpe M; Foster Page L. Author NameID Schwendicke, Falk; ORCID: http://orcid.org/0000-0003-1223-1669 Thomson, William Murray; ORCID: http://orcid.org/0000-0003-0588-6843 Foster Page, Lyndie; ORCID: http://orcid.org/0000-0001-5671-6356 Authors Full Name Schwendicke, Falk; Splieth, Christian H; Thomson, William Murray; Reda, Seif; Stolpe, Michael; Foster Page, Lyndie. Institution Schwendicke, Falk. Department of Operative and Preventive Dentistry, Charite Universitatsmedizin Berlin, Berlin, Germany. Splieth, Christian H. Department of Preventive and Pediatric Dentistry, Universitatsmedizin Greifswald, Greifswald, Germany. Thomson, William Murray. Department of Oral Sciences, Faculty of Dentistry, University of Otago, Otago, New Zealand. Reda, Seif. Department of Operative and Preventive Dentistry, Charite Universitatsmedizin Berlin, Berlin, Germany. Stolpe, Michael. Kiel Institute for the World Economy, Kiel, Germany. Foster Page, Lyndie. Department of Oral Sciences, Faculty of Dentistry, University of Otago, Otago, New Zealand. Title Cost-effectiveness of caries-preventive fluoride varnish applications in clinic settings among patients of low, moderate and high risk. Source Community Dentistry & Oral Epidemiology. , 2017 Jul 06. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVES: The total body of evidence finds fluoride varnish effective to prevent caries. However, most trials were conducted in high-risk populations, with more recent trials on low-risk groups finding a lower efficacy. We aimed to assess the costeffectiveness of fluoride varnish application in clinic setting in populations with different caries risk.OBJECTIVES: The total body of evidence finds fluoride varnish effective to prevent caries. However, most trials were conducted in high-risk populations, with more recent trials on low-risk groups finding a lower efficacy. We aimed to assess the costeffectiveness of fluoride varnish application in clinic setting in populations with different caries risk. METHODS: A mixed public-private-payer perspective in the context of German health care was performed using a lifetime Markov model. Effectiveness data were derived from an update of the most recent systematic Cochrane review and synthesized in three different risk groups according to control group caries increment via random-effects meta-analysis. Varnish was assumed to be applied twice yearly between age 6 and 18 years. Teeth with carious defects would be treated restoratively and could experience further follow-up treatments. Costs were deduced from German fee item catalogues. Monte Carlo microsimulations were used for to analyse lifetime treatment costs and caries increment (Euro/Decayed, Missing, Filled Teeth (DMFT)). RESULTS: In low-risk groups, fluoride varnish was nearly twice as costly and minimally more effective (293 Euro, 8.1 DMFT) than no varnish (163 Euro, 8.5 DMFT). The incremental cost-effectiveness ratio (ICER) was 343 Euro spent per avoided DMFT. The ICER was lower in medium-risk (ICER 93 Euro/DMFT) and high-risk groups (8 Euro/DMFT). CONCLUSIONS: Application of fluoride varnish in the clinic setting is unlikely to be cost-effective in low-risk populations. There is the need to either target high-risk groups or to provide fluoride varnish at lower costs, possibly in nonclinic settings. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Date Created 20170706 Year of Publication 2017 <3> Unique Identifier 28668961 VI 1 Status Publisher Authors Piekoszewska-Zietek P; Turska-Szybka A; Olczak-Kowalczyk D. Authors Full Name Piekoszewska-Zietek, Paula; Turska-Szybka, Anna; Olczak-Kowalczyk, Dorota. Institution Piekoszewska-Zietek, Paula. Department of Paediatric Dentistry, Medical University of Warsaw, Warsaw, Poland. Title Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review. Source Caries Research. 51(4):425-435, 2017 Jul 01. Local Messages BDA LIBRARY MEDLINE SEARCH RECENT REVIEWS RELATED TO DENTAL CARIES THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract Recent progress in the field of molecular biology and techniques of DNA sequence analysis allowed determining the meaning of hereditary factors of many common human diseases. Studies of genetic mechanisms in the aetiology of caries encompass, primarily, 4 main groups of genes responsible for (1) the development of enamel, (2) formation and composition of saliva, (3) immunological responses, and (4) carbohydrate metabolism. The aim of this study was to present current knowledge about the influence of single nucleotide polymorphism (SNP) genetic variants on the occurrence of dental caries. PubMed/Medline, Embase, and Cochrane Library databases were searched for papers on the influence of genetic factors connected with SNP on the occurrence of dental caries in children, teenagers, and adults. Thirty original papers written in English were included in this review. Study groups ranged from 30 to 13,000 subjects. SNPs were observed in 30 genes. Results of the majority of studies confirm the participation of hereditary factors in the aetiology of caries. Three genes, AMELX, AQP5, and ESRRB, have the most promising evidence based on multiple replications and data, supporting a role of these genes in caries. The review of the literature proves that SNP is linked with the aetiology of dental caries. Copyright © 2017 S. Karger AG, Basel. Publication Type Journal Article. Date Created 20170702 Year of Publication 2017 <4> Unique Identifier 28652063 VI 1 Status Publisher Authors Schwendicke F; Innes N; Levey C; Lamont T; Gostemeyer G. Authors Full Name Schwendicke, Falk; Innes, Nicola; Levey, Colin; Lamont, Thomas; Gostemeyer, Gerd. Institution Schwendicke, Falk. Department of Operative and Preventive Dentistry, Charite Universitatsmedizin Berlin, Germany. Innes, Nicola. Paediatric Dentistry, Dundee Dental Hospital and School, University of Dundee, Dundee, UK. Levey, Colin. Department of Restorative Dentistry, Dundee Dental Hospital and School, University of Dundee, Dundee, UK. Lamont, Thomas. Department of Restorative Dentistry, Dundee Dental Hospital and School, University of Dundee, Dundee, UK. Gostemeyer, Gerd. Department of Operative and Preventive Dentistry, Charite Universitatsmedizin Berlin, Germany. Electronic address: [email protected]. Title Comparator choice in caries prevention and management trials. Source Journal of Clinical Epidemiology. , 2017 Jun 23. Abstract Comparator choice has been found one major factor impacting on the overall evidence supporting clinical interventions. We performed social network analysis on trials on the prevention/management of caries/carious lesions, hypothesizing that certain comparators are proportionally over-investigated, and others under-investigated, and that comparisons within comparator classesComparator choice has been found one major factor impacting on the overall evidence supporting clinical interventions. We performed social network analysis on trials on the prevention/management of caries/carious lesions, hypothesizing that certain comparators are proportionally over-investigated, and others under-investigated, and that comparisons within comparator classes are preferred over comparisons between classes. A systematic review of randomized controlled trials on the prevention/management of caries/existing carious lesions was carried out. All comparators were classified at each of three levels of granularity, becoming more detailed with each level; (a) degree of invasiveness (non-, microor invasive), (b) the specific noninvasive, micro-invasive or invasive approach, (c) the actual material or technique used. Social network analysis was used to evaluate trial networks. Searching electronic databases found 4,774 articles of which 765 were relevant and 605 were included. The networks for all levels were polygonal. There was a high degree of separation of comparisons in prevention versus management trials. Invasive comparators were tested most frequently (number of comparators: 611), mainly in management trials. Non-invasive comparators were tested next often (474), mainly in caries prevention. Micro-invasive strategies were tested next often (233), in both, prevention and management trials. On more granular levels, few interventions dominated the networks. Regardless of the level, the majority of trials compared within, not between classes. Prevention trials were mainly conducted in children (number of trials in adults/children/both: 37/241/11), while those on managing lesions were conducted in both children and adults (117/179/21). Comparator choice in cariology trials is driven by indication, and limits conclusions on the true comparative effectiveness of all strategies. There are a variety of comparators that have not been, but should be, compared to one another, which should be addressed by future trials. Factors underlying trialists' comparator choice need to be identified. Copyright © 2017. Published by Elsevier Inc. Publication Type Journal Article. Date Created 20170627 Year of Publication 2017